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Journal of the American Chemical Society

Basic Esters and Quaternary Derivatives of β-Hydroxy Acids as Antispasmodics1

GR Treves, FC Testa

文献索引:Treves; Testa Journal of the American Chemical Society, 1952 , vol. 74, p. 46

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被引用次数: 7

摘要

A series of basic esters of (1-hydroxycycloalky1)-arylacetic acids is described. Eighteen new compounds were synthesized and isolated as hydrochlorides and quaternary methiodides. Preliminary work done in our pharmacological laboratory shows that several members of our series possess neurotropic activity comparable to that of atropine and musculotropic activity of the order of magnitude of papaverine.