Nucleosides, Nucleotides & Nucleic Acids 2003-01-01

A novel PNA-monomer for recognition of thymine in triple-helix structures.

Anne Goldbech Olsen, Otto Dahl, Peter E Nielsen

文献索引：Nucleosides Nucleotides Nucleic Acids 22(5-8) , 1331-3, (2003)

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摘要

To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.