Synthesis and Evaluation of the α-d-/α-l-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Antitumor Agents

…, Y Rojanasakul, GA O'Doherty

文献索引：Wang, Hua-Yu Leo; Rojanasakul, Yon; O'Doherty, George A. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 4 p. 264 - 269

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被引用次数: 38

摘要

A highly regio-and stereoselective asymmetric synthesis of rhamnosyl-and amicetosyl- digitoxigenin analogues has been established via palladium-catalyzed glycosylation followed by bis-/tris-dihydroxylation or bis-/tris-diimide reduction. The α-l-rhamnose and α-l- amicetose digitoxin monosaccharide analogues displayed stronger apoptosis inducing activity and cytotoxicity against nonsmall cell human lung cancer cells (NCI-H460) than its ...