Homologation of α-amino acids to β-amino acids using Boc2O
GR Vasanthakumar, BS Patil, VVS Babu
文献索引：Vasanthakumar, Ganga-Ramu; Patil, Basanagoud S.; Suresh Babu, Vommina V. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 18 p. 2087 - 2089
The use of Boc2O as a coupling agent in the homologation of N-urethane protected-α-amino acid to its β-homomers by the Arndt–Eistert method is described. The homologation gives good yields without racemization. The use of Boc2O as a coupling agent not only allows the easy scale up of the process but also it is cost effective.
