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Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

F Buller, L Mannocci, Y Zhang, CE Dumelin…

文献索引:Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 22 p. 5926 - 5931

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被引用次数: 57

摘要

... Bioorganic & Medicinal Chemistry Letters. ... The isolation of small organic molecules, capable of specific binding to proteins, is a central problem in chemistry, biology, and medicine. ... These hits are then selected for further optimization by medicinal chemistry. ...