Zwitterionic oligonucleotides: a study on binding properties of 2′-O-aminohexyl modifications

…, M Gilbert, G Haberhauer, H Brunar

文献索引：Noe, Christian R.; Winkler, Johannes; Urban, Ernst; Gilbert, Matthias; Haberhauer, Georg; Brunar, Helmut Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 8 p. 1167 - 1185

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被引用次数: 19

摘要

2′-O-Aminohexyl side chains provide excellent conditions for zwitterionic interstrand and intrastrand interactions of oligonucleotides. 2′-O-Aminoalkylated phosphoramidites of adenosine and uridine were synthesized and incorporated in increasing number into homo adenosine and homo uridine/thymidine dodecamers, respectively. CD spectra of these dodecamers with complementary sense DNA exhibited a B-DNA type structure. While ...