Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors
Suk-Yun Kang, Chi-Young Kim, Dae-Hyun Roh, Seo-Yeon Yoon, Ji-Ho Park, Hye-Jung Lee, Alvin J. Beitz, Jang-Hern Lee
Highlights ► DBV's anti-nociceptive effect involves suppression of spinal astrocyte activation. ► DBV-induced astrocyte inhibition is mediated by spinal alpha-2A and alpha-2C adrenoceptors. ► Astrocyte modulation by DBV is potentiated by i.t. administration of fluorocitrate.