Synthesis and bioevaluation of a series of fatty acid esters of p??[N, N??bis (2??chloroethyl) amino] phenol

…, ML Caldwell, JR Robinson, RL Beamer…

文献索引：Wynn; Caldwell; Robinson; Beamer; Bauguess Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 7 p. 772 - 776

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被引用次数: 6

摘要

Abstract A series of even numbered fatty acid esters (C 2 [BOND] C 18) of p-[N, N-bis (2- chloroethyl) amino] phenol were synthesized and evaluated as to acute toxicity as well as effectiveness against L-1210 mouse leukemia. The acetate through the decanoate derivatives demonstrated toxicity between 2 and 3 times that of phenol mustard in HA/ICR mice. The less soluble laurate, myristate, palmitate, and stearate derivatives were less ...