Palladium catalysed aryl amination reactions in supercritical carbon dioxide

…, MWS Tsang, AB Holmes, RL Danheiser…

文献索引：Smith, Catherine J.; Tsang, Melanie W.S.; Holmes, Andrew B.; Danheiser, Rick L.; Tester, Jefferson W. Organic and Biomolecular Chemistry, 2005 , vol. 3, # 20 p. 3767 - 3781

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被引用次数: 46

摘要

Palladium catalysed C–N bond formation in supercritical carbon dioxide has been accomplished. Carbamic acid formation is avoided in part through the use of an N-silylamine as the coupling partner. Employing a catalyst system of Pd2dba3 (1 mol%) and 2- dicyclohexylphosphino-2′, 4′, 6′-triisopropyl-1, 1′-biphenyl (X-Phos)(2 mol%) enabled the catalytic amination of aryl bromides and chlorides with N-silylanilines to be realised in ...