Synthesis of 1, 2-disubstituted acetylenes via copper-catalyzed Suzuki coupling of organoboronic acids with 1, 1-dibromo-1-alkenes

J Liu, F Dai, Z Yang, S Wang, K Xie, A Wang, X Chen…

文献索引：Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683

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被引用次数: 8

摘要

An efficient synthesis of 1, 2-disubstituted acetylenes has been described. Reactions of organoboronic acids with 1, 1-dibromo-1-alkenes in the presence of a catalytic amount of CuI (10mol%), 8-hydroxyquinoline (10mol%), and using potassium phosphate as base in C2H5OH afforded the desired 1, 2-disubstituted acetylenes in good to excellent yields. It is important to note that the formation of 1, 3-diynes, which are derived from the ...

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