Chemistry Letters

DEFLUORINATION REACTIONS OF gem-DIFLUORO-AND MONOFLUOROOLEFINS. NOVEL METHODS FOR ONE-CARBON HOMOLOGATIONS OF CARBONYL …

S Hayashi, T Nakai, N Ishikawa

文献索引：Hayashi, Sei-ichi; Nakai, Takeshi; Ishikawa, Nobuo Chemistry Letters, 1980 , p. 651 - 654

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被引用次数: 14

摘要

Defluorinative hydrolysis (or alcoholysis) of gem-difluoroolefins (1) easily prepared via the facile difluoromethylenation of carbonyl compounds afforded the carboxylic acids (or esters). The homologation method was applied to the synthesis of anti-inflammatory ibuprofen. Furthermore, defluorinative hydrolysis of monofluoroolefins obtained via the reduction of 1 gave the aldehydes.