Organic Letters 2003-04-03

Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base.

Peter Wipf, Stephen M Lynch

文献索引：Org. Lett. 5(7) , 1155-8, (2003)

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摘要

[reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.