Synthesis of Aryl Ketones by Palladium (II)??Catalyzed Decarboxylative Addition of Benzoic Acids to Nitriles

J Lindh, PJR Sjöberg, M Larhed

文献索引：Lindh, Jonas; Sjoeberg, Per J. R.; Larhed, Mats Angewandte Chemie - International Edition, 2010 , vol. 49, # 42 p. 7733 - 7737

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被引用次数: 77

摘要

Ketones are a common functionality in many types of organic compounds for example, pharmaceuticals and natural products. In 2004, Larock reported novel reactions of arenes or arylboronic acids with nitriles to generate aryl ketones by hydrolysis of the intermediate ketimine.[1] This pioneering work on carbon–transition-metal bond insertions into polar carbonÀnitrogen triple bonds has since been followed by a number of related reports.[2] ...