Organic letters

Synthesis of 3-acylindoles by palladium-catalyzed acylation of free (N–H) indoles with nitriles

TS Jiang, GW Wang

文献索引：Jiang, Tao-Shan; Wang, Guan-Wu Organic Letters, 2013 , vol. 15, # 4 p. 788 - 791

全文：HTML全文

被引用次数: 45

摘要

An efficient palladium-catalyzed synthesis of 3-acylindoles using free (N–H) indoles and nitriles has been developed. The acylation reaction proceeded well under the Pd (OAc) 2/2, 2′-bipyridine system and with d-(+)-camphorsulfonic acid as the additive. A possible mechanism involving carbopalladation of nitriles and subsequent hydrolysis of ketimines is proposed.