Tetrahedron Letters

Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines

L Liu, Y Wang, H Wang, C Peng, J Zhao, Q Zhu

文献索引：Liu, Lanying; Wang, Yong; Wang, Honggen; Peng, Changlan; Zhao, Jiaji; Zhu, Qiang Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6715 - 6719

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被引用次数: 21

摘要

A highly efficient one-pot synthesis of 2-chloro-3-substituted quinolines has been developed by tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes, which are generated in situ by dehydration of the corresponding N-(2-ethynylphenyl) formamides.