Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

…, M Le Borgne, F Pagniez, G Le Baut, P Le Pape

文献索引：Na, Young-Min; Le Borgne, Marc; Pagniez, Fabrice; Le Baut, Guillaume; Le Pape, Patrice European Journal of Medicinal Chemistry, 2003 , vol. 38, # 1 p. 75 - 87

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被引用次数: 36

摘要

A series of 1-benzyl-3-(imidazol-1-ylmethyl) indole derivatives 35–46 were prepared under mild reaction conditions and tested for their antifungal activity. Pharmacomodulation at N1, C2 and C5 of the indole ring and at the level of the alkyl chain (R1) was carried out starting from the corresponding 3-acylindoles 6, 7 or 3-formylindoles 11–22. Target imidazolyl compounds 35–46 were obtained in satisfactory yields by CO2 elimination from the ...