Tetrahedron letters

Rapid purification of small molecule libraries by ion exchange chromatography

…, BA Dressman, JE Fritz, JR Grunwell, SW Kaldor

文献索引：Siegel, Miles G.; Hahn, Patric J.; Dressman, Bruce A.; Fritz, James E.; Grunwell, Jocelyn R.; Kaldor, Stephen W. Tetrahedron Letters, 1997 , vol. 38, # 19 p. 3357 - 3360

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被引用次数: 139

摘要

Amines and acylated amines are synthesized in traditional solution phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. In some instances, impurities devoid of ionizable functionality can be covalently modified prior to purification. The generic purification sequence is applicable to a variety of reactions, and is amenable to automation with commercially available equipment.