2-(2-Arylphenyl) benzoxazole As a Novel anti-inflammatory scaffold: synthesis and biological evaluation

K Seth, SK Garg, R Kumar, P Purohit…

文献索引：Kumar, Dinesh; Rudrawar, Santosh; Chakraborti, Asit K. Australian Journal of Chemistry, 2008 , vol. 61, # 11 p. 881 - 887

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被引用次数: 17

摘要

The 2-(2-arylphenyl) benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl) benzoxazoles 3a–m have been synthesized by Suzuki reaction of 2-(2-bromophenyl) benzoxazole. Further synthetic