Design of β-secretase inhibitors by introduction of a mandelyl moiety in DAPT analogues

N Pietrancosta, G Quéléver, Y Laras, C Garino…

文献索引：Australian Journal of Chemistry, , vol. 58, # 8 p. 585 - 594

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被引用次数: 9

摘要

... 8 9 XH 10 X OH ... rt; 73%; ( j) 3,5-difluoromandelic acid, Cl3COCOCl, activated charcoal, THF, rt[15] then DIEA, CH2Cl2, rt; 26%; (k) LiOH, CaCl2, PriOH/H2O, rt;[14,16] 58% (19),[14 ... Chemical shifts are expressed as δ units (part per million) downfield from TMS (tetramethylsilane). ...