Synthesis of Novel 5′-Uridine-Head Amphiphiles as Model for DNA Molecular Recognition

M Tiecco, P Di Profio, R Germani…

文献索引：Tiecco, Matteo; Di Profio, Pietro; Germani, Raimondo; Savelli, Gianfranco Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 10 p. 911 - 923

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被引用次数: 5

摘要

Here we describe uridine functionalization in the 5′ position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.