Organic letters

Ortho-lithiophenyl isocyanide: a versatile precursor for 3 H-quinazolin-4-ones and 3 H-quinazolin-4-thiones

AV Lygin, A Meijere

文献索引：Lygin, Alexander V.; De Meijere, Armin Organic Letters, 2009 , vol. 11, # 2 p. 389 - 392

全文：HTML全文

被引用次数: 46

摘要

Isocyanides have found a wide range of applications in organic synthesis,(1) particularly in the synthesis of heterocycles.(2) The electron-withdrawing effect of the isocyano group enhances the acidity of α-C,H bonds, and this was first exploited by Schöllkopf and Gerhart(3) (Figure 1) in 1968. Since then, α-metallated isocyanides have been shown to participate in various types of cocyclizations leading to different nitrogen-containing heterocycles.(4) Conversely, the ...