General strategy for large-scale synthesis of (+)-rivastigmine and (+)-nps r-568

…, MP Shewalkar, R Nandipati, JS Yadav…

文献索引：Rao, Ramakrishna; Shewalkar, Mukesh Padmakar; Nandipati, Ramadevi; Yadav, Jhillu Singh; Khagga, Mukkanti; Shinde, Devanand Baburao Synthetic Communications, 2012 , vol. 42, # 4 p. 589 - 598

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被引用次数: 5

摘要

A specific stereoisomer of a pharmaceutical drug having one or more stereogenic center tends to be responsible for the biological activity. In some cases, the other isomer could cause damaging side effects. [ 1 1. Rouhi , AM Chiral business . Chem. Eng. News 2003 , 81 ( 18 ), 45 – 55 . [CrossRef], [Web of Science ®] View all references ] The therapeutic inactive isomer is regarded as an impurity that possesses different or undesirable pharmacological activity. This ...