Chemical Communications 2011-02-14

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.

Nicholas T Salzameda, Lisa M Eubanks, Joseph S Zakhari, Kyoji Tsuchikama, Nicholas J DeNunzio, Karen N Allen, Mark S Hixon, Kim D Janda

文献索引：Chem. Commun. (Camb.) 47(6) , 1713-5, (2011)

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摘要

Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity.