Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis (trifluoromethyl) phenyl) …
We investigated the structure-activity relationship studies of N-[3, 5-bis (trifluoromethyl) phenyl][2-chloro-4-(trifluoromethyl) pyrimidin-5-yl] carboxamide (1), an inhibitor of transcription mediated by both NF-κB and AP-1 transcription factors, with the goal of improving its potential oral bioavailability. Compounds were examined for cell-based activity, were fit to Lipinski's rule of 5, and were examined for potential gastrointestinal ...
![ethyl 2-[(carbamoylamino)methylidene]-3-oxo-butanoate结构式](https://image.chemsrc.com/caspic/139/6319-01-3.png)
