The palladium-catalyzed trifluoromethylation of aryl chlorides

…, T Kinzel, Y Zhang, DA Watson, SL Buchwald

文献索引：Cho, Eun Jin; Senecal, Todd D.; Kinzel, Tom; Zhang, Yong; Watson, Donald A.; Buchwald, Stephen L. Science, 2010 , vol. 328, # 5986 p. 1679 - 1681

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被引用次数: 426

摘要

Abstract The trifluoromethyl group can dramatically influence the properties of organic molecules, thereby increasing their applicability as pharmaceuticals, agrochemicals, or building blocks for organic materials. Despite the importance of this substituent, no general method exists for its installment onto functionalized aromatic substrates. Current methods either require the use of harsh reaction conditions or suffer from a limited substrate scope. ...