Synthesis and antitumor evaluation in mice of certain 7-deazapurine (pyrrolo [2, 3-d] pyrimidine) and 3-deazapurine (imidazo [4, 5-c] pyridine) nucleosides structurally …

K Ramasamy, N Imamura, NB Hanna…

文献索引：Ramasamy, Kandasamy; Imamura, Nobutaka; Hanna, Naeem B.; Finch, Rick A.; Avery, Thomas L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1220 - 1225

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被引用次数: 31

摘要

7-Deaza (pyrrolo [2, 3-d] pyrimidine) and 3-deaza (imidezo [4, 5c] pyridine) congeners of sulfenoeine (5a and 9), sulfiinosine (6a and lo), and sulfonosine (7a) have been prepared and evaluated for their antileukemic activity in mice. Amiiation of 2-amino-7-~-D- ribofuranosylpyrrolo [2, 3-d] pyrimidine-4 (3H)-thione (4a) and ita 2'-deoxy analogue (4c) with a chloramine solution gave the corresponding 4-sulfenamides (5a and 5c, ...