Potassium on alumina as a reagent for reductive decyanation of alkylnitriles

…, C Trombini, A Umani-Ronchi

文献索引：Savoia, Diego; Tagliavini, Emilio; Trombini, Claudio; Umani-Ronchi, Achille Journal of Organic Chemistry, 1980 , vol. 45, # 16 p. 3227 - 3229

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被引用次数: 42

摘要

70 the usefulness of this method. For this purpose 6-bromo-1-hexanol (3), prepared from 1, 6-hexandiol according to B~ tenandt,'~ is converted into la through CN-displacement under phase-transfer conditions, 14 followed by protection of the hydroxyl group as the THP derivative. Metalation of la with lithium diisopropylamide and alkylation with (Z)-l-iodo-3- hexene affords lb. The elimination of the cyano group in lb is easily accomplished in ...