Facile synthesis of ethynylated benzoic acid derivatives and aromatic compounds via ethynyltrimethylsilane

WB Austin, N Bilow, WJ Kelleghan…

文献索引：Austin, William B.; Bilow, Norman; Kelleghan, William J.; Lau, Kreisler S. Y. Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2280 - 2286

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被引用次数: 396

摘要

The coupling reaction between an aromatic halide and ethynyltrimethylsilane under the catalysis of palladium (0) generated in situ, followed by treatment of the (trimethylsily1) ethynyl product with potassium carbonate in methanol at ambient temperatures, provides a simple approach to various ethynylated benzoic acid derivatives and other aromatic compounds. The conditions for the removal of the trimethylsilyl group were very mild, so ...