Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol

…, RL Geahlen, M Cushman

文献索引：Thakkar, Kshitij; Geahlen, Robert L.; Cushman, Mark Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2950 - 2955

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被引用次数: 167

摘要

A series of hydroxylated trans-stilbenes related to the antileukemic natural product trans-3, 3', 4, 5'-tetrahydroxystilbene (piceatannol)(1) has been prepared and tested for inhibition of the lymphoid cell lineage-specific protein-tyrosine kinase p56lCk, which plays an important role in lymphocyte proliferation and immune function. A number of the analogues displayed enhanced enzyme inhibitory activity relative to the natural product. Reduction of the ...