Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7 H-[1, 4] Oxazino [3, 2-g] quinolin-7-ones

RI Higuchi, KL Arienti, FJ López, NS Mani…

文献索引：Higuchi, Robert I.; Arienti, Kristen L.; Lopez, Francisco J.; Mani, Neelakhanda S.; Mais, Dale E.; Caferro, Thomas R.; Long, Yun Oliver; Jones, Todd K.; Edwards, James P.; Zhi, Lin; Schrader, William T.; Negro-Vilar, Andres; Marschke, Keith B. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2486 - 2496

全文：HTML全文

被引用次数: 38

摘要

Recent interest in orally available androgens has fueled the search for new androgens for use in hormone replacement therapy and as anabolic agents. In pursuit of this, we have discovered a series of novel androgen receptor modulators derived from 7 H-[1, 4] oxazino [3, 2-g] quinolin-7-ones. These compounds were synthesized and evaluated in competitive binding assays and an androgen receptor transcriptional activation assay. A number of ...