Using (R)-or (S)-1-phenylethylamine as a resolving agent,(R)-and (S)-4-cyano-4-(4- nitrophenyl) hexanoic acids have been isolated. Cyclization of each enantiomer, followed by reduction of the nitro group, afforded (R)-and (S)-aminoglutethimide of high (> 99% ee) enantiomeric purity, respectively. The absolute configuration of (R)-(+)-3-(4-nitrophenyl)-3- ethylpiperidine-2, 6-dione was solved by X-ray single crystal analysis thus establishing ...
