Tetrahedron letters

A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl) pyridine (SIB-1508Y) from (S)-nicotine

DL Comins, ED Smith

文献索引：Comins, Daniel L.; Smith, Emilie D. Tetrahedron Letters, 2006 , vol. 47, # 9 p. 1449 - 1451

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被引用次数: 21

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The anti-Parkinson's agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate. ... Nicotine (1) and SIB-1508Y (2). Nicotine (1) and SIB-1508Y (2).