Dermatology 2015-01-01

Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study.

Hesham Zaher, Heba I Gawdat, Rehab A Hegazy, Marwa Hassan

文献索引：Dermatology 230 , 308-13, (2015)

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摘要

Alopecia areata (AA) is an immune-mediated disease that targets anagen hair follicles. Despite various therapeutic options, there is no cure for AA. Prostaglandin analogues have been recognized as being capable of inducing hypertrichosis.To compare the efficacy and safety of bimatoprost to those of corticosteroid in the treatment of scalp AA.Thirty adult patients with patchy AA (S1) were included. Two AA patches were randomly assigned to treatment either by mometasone furoate 0.1% cream once daily (area A) or bimatoprost 0.03% solution twice daily (area B) for 3 months. Patients were assessed using the Severity of Alopecia Tool (SALT) scoring system for hair re-growth.All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A.Bimatoprost solution represents a therapeutic option for scalp AA.