Molecules 2013-01-01

Synthesis of new 1,2,3-triazole derivatives of uracil and thymine with potential inhibitory activity against acidic corrosion of steels.

Guillermo E Negrón-Silva, Rodrigo González-Olvera, Deyanira Angeles-Beltrán, Nidia Maldonado-Carmona, Araceli Espinoza-Vázquez, Manuel E Palomar-Pardavé, Mario A Romero-Romo, Rosa Santillan

文献索引：Molecules 18(4) , 4613-27, (2013)

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摘要

Ten 1,4-disubstituted 1,2,3-triazoles were synthesized from one of 1-(azido-methyl)benzene, 1-(azidomethyl)-4-fluorobenzene, 1-(azidomethyl)-4-chlorobenzene, 1-(azidomethyl)-4-bromobenzene or 1-(azidomethyl)-4-iodobenzene, generated in situ from sodium azide and the corresponding benzyl halide, and dipropargyl uracil or dipropargyl thymine. Optimal experimental conditions were established for the conventional click chemistry. The corrosion inhibiting properties of some of these compounds, which were determined by means of an electrochemical technique, are also presented.