Bioactivation of S-(2, 2-dihalo-1, 1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate β-lyase: indications for formation of both …

JNM Commandeur, LJ King, L Koymans…

文献索引：Commandeur, Jan N. M.; King, Laurence J.; Koymans, Luc; Vermeulen, Nico P. E. Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1092 - 1102

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被引用次数: 18

摘要

The covalent binding of reactive intermediates, formed by β-elimination of cysteine S- conjugates of halogenated alkenes, to nucleophiles was studied using 19F-NMR and GC- MS analysis. β-Elimination reactions were performed using rat renal cytosol and a β-lyase model system, consisting of pyridoxal and copper (II) ion. S-(1, 1, 2, 2-Tetrafluoroethyl)-l- cysteine (TFE-Cys) was mainly converted to products derived from difluorothionoacetyl ...