Journal of Fluorine Chemistry

Organocatalysis approach to trifluoromethylation with fluoroform

Y Zhang, M Fujiu, H Serizawa, K Mikami

文献索引：Zhang, Yuan; Fujiu, Motohiro; Serizawa, Hiroki; Mikami, Koichi Journal of Fluorine Chemistry, 2013 , vol. 156, p. 367 - 371

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被引用次数: 12

摘要

Abstract The organic base methodology exploits an access to generate the “trifluoromethyl anion” for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P 4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation ...