Organic Letters 2008-12-18

In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.

Mingyu Hu, Junqi Li, Shao Q Yao

文献索引：Org. Lett. 10(2) , 5529-5531, (2008)

摘要

A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.

结构式	名称/CAS号	分子式	全部文献
	1-Azido-4-fluorobenzene solution CAS:3296-02-4	C₆H₄FN₃

Decomposition of halogen-substituted phenyl azides Smalley, ...
[J. Chem. Soc. , 5922-5925, (1964)]

In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.

摘要

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