Xenobiotica

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance

K Zomorodi, DJ Carlile, JB Houston

文献索引：Xenobiotica, , vol. 25, # 9 p. 907 - 916

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被引用次数: 53

摘要

Page 1. XENOBIOTICA, 1995, VOL. 25, NO. ... After oral administration, DZ absorption is both fast and complete (Guentert 1984). DZ has considerable lipophilic properties, is extensively bound to plasma proteins and has a large steady-state volume of distribution of 3-1 1 l/kg. ...