The discovery of antimalarial activity in 5-(4'-chlorophenoxy)-2, 4-diaminopyrimidine1 and its 6-methyl homol~ g~~~ indicated the desirability of the preparation and testing of various related structures. The oxygen atom of the phenoxypyrimidine was viewed as a connecting group of unknown importance between the pyrimidine and benzene nuclei. The preparation of similar substances with various atoms and groups, including nitrogen, sulfur and carbon ...
