Bioorganic & Medicinal Chemistry Letters 2009-09-01

Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.

Idriss Bennacef, Cristian A Salinas, Thomas A Bonasera, Roger N Gunn, Hélène Audrain, Steen Jakobsen, Nabeel Nabulsi, David Weinzimmer, Richard E Carson, Yiyun Huang, Ian Holmes, Fabrizio Micheli, Christian Heidbreder, Gabriella Gentile, Tino Rossi, Marc Laruelle

文献索引：Bioorg. Med. Chem. Lett. 19 , 5056-5059, (2009)

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摘要

Compound 1 is a potent and selective antagonist of the dopamine D(3) receptor. With the aim of developing a carbon-11 labeled ligand for the dopamine D(3) receptor, 1 was selected as a potential PET probe. [(11)C]1 was obtained by palladium catalyzed cross coupling using [(11)C]cyanide and 4 with a specific activity of 55.5+/-25.9GBq/micromol (1.5+/-0.7Ci/micromol). [(11)C]1 was tested in porcine and non-human primate models to assess its potential as a radioligand for PET imaging of the dopamine D(3) receptor. We conclude that in both species and despite appropriate in vitro properties, [(11)C]1 does not show any specific signal for the dopamine D(3) receptor.