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Acta Pharmaceutica 2006-09-01

Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.

Ahmed H Bedair, Fawzy M Ali, Ahmed M El-Agrody, Fathy A Eid, Mohammed A A El-Nassag, Gamal El-Sherbeny

文献索引:Acta. Pharm. 56(3) , 273-84, (2006)

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摘要

Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.

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