Synthesis of Methylene??Bridge Polyarenes through Palladium??Catalyzed Activation of Benzylic Carbon??Hydrogen Bond

CC Hsiao, YK Lin, CJ Liu, TC Wu…

文献索引：Hsiao, Chien-Chi; Lin, Yi-Kuan; Liu, Chia-Ju; Wu, Tsun-Cheng; Wu, Yao-Ting Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3267 - 3274

全文：HTML全文

被引用次数: 25

摘要

Abstract In the presence of palladium (II) acetate [Pd (OAc) 2] and an N-heterocyclic carbene (NHC) ligand, fluorene derivatives can be generated in good to excellent yields from 2-halo- 2′-methylbiaryls through the benzylic C [BOND] H bond activation (14 examples; 81–97% yields). The scope and limitations of this protocol have been examined. A wide range of functional groups, such as alkyl, alkoxy, ester, nitrile, and others, is able to tolerate the ...