Tetrahedron Letters

Regioselective ortho lithiation of halopyridines

GW Gribble, MG Saulnier

文献索引：Gribble, Gordon W.,; Saulnier, Mark G. Tetrahedron Letters, 1980 , vol. 21, p. 4137 - 4140

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被引用次数: 113

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Regioselective ortho lithiation of 2-, 3-, and 4-halopyridines is achieved with lithium diisopropylamide (−78°, tetrahydrofuran) to afford, upon quenching with electrophilic reagents, 2,3- and 3,4-disubstituted pyridines in good to excellent yield. ... This effectively separates the chloroiodopyridines ...