A short synthetic approach toward a novel class of chiral nucleophilic catalysts, the dissymmetry of which stems from restricted rotation about an Ar-Ar bond, has been developed. The key steps of the synthesis include preparation of a nucleophilic 1-methyl-2- pyrrolino [3, 2-c] pyridine core 16 by ortho-lithiation and creation of the biaryl axes via Suzuki cross-coupling reactions. Comparative HPLC studies of racemization for configurationally ...
![1H-Pyrrolo[3,2-c]pyridine,2,3-dihydro-1-methyl-(9CI)结构式](https://image.chemsrc.com/caspic/075/219834-79-4.png)