前往化源商城

Bioorganic & Medicinal Chemistry Letters 2006-10-15

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.

Gerhard Puerstinger, Jan Paeshuyse, Piet Herdewijn, Jef Rozenski, Erik De Clercq, Johan Neyts

文献索引:Bioorg. Med. Chem. Lett. 16(20) , 5345-9, (2006)

全文:HTML全文

摘要

A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).

相关化合物

结构式 名称/CAS号 全部文献
2,6-二氟溴苄 结构式 2,6-二氟溴苄
CAS:85118-00-9