Chemical Communications 2012-11-14

A highly selective fluorescent probe for fast detection of hydrogen sulfide in aqueous solution and living cells.

Zheng Xu, Lin Xu, Ji Zhou, Yufang Xu, Weiping Zhu, Xuhong Qian

文献索引：Chem. Commun. (Camb.) 48(88) , 10871-3, (2012)

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摘要

A new ratiometric fluorescence probe E1 based on an excited-state intramolecular proton transfer (ESIPT) mechanism for detection of hydrogen sulfide (H(2)S) is reported. E1 responds to H(2)S quickly and showed a 30-fold fluorescence enhancement in 2 minutes. Moreover, E1 can detect H(2)S quantitatively with a detection limit as low as 0.12 μM in aqueous solution. Its potential for biological applications was confirmed by employing it for fluorescence imaging of H(2)S in living cells.