Synthesis

Highly stereo-and chemoselective iron-catalyzed alkenylation of organomagnesium compounds

G Cahiez, H Avedissian

文献索引：Cahiez, Gerard; Avedissian, Hovsep Synthesis, 1998 , # 8 p. 1199 - 1205

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被引用次数: 166

摘要

Abstract: In the presence of Fe (acac) 3, Grignard reagents react readily with alkenyl halides (X= I, Br or Cl) in a THF/NMP mixture to give the cross-coupling products in high yields with an excellent stereoselectivity (≥ 99.5%). The scope of the reaction is very broad since a vast array of functional groups are tolerated (esters, nitriles, aromatic or aliphatic halides and even ketones). The procedure reported herein is an interesting alternative to the classical ...