Tetrahedron

Asymmetric synthesis catalyzed by chiral ferrocenylphosphine transition metal complexes. 10 gold (i)-catalyzed asymmetric aldol reaction of isocyanoacetate

T Hayashi, M Sawamura, Y Ito

文献索引：Hayashi, Tamio; Sawamura, Masaya; Ito, Yoshihiko Tetrahedron, 1992 , vol. 48, # 11 p. 1999 - 2012

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被引用次数: 122

摘要

Optically active ferrocenylbisphosphine ligands containing 2-(dialkylamino) ethylamino group on the ferrocenylmethyl position have been prepared and used for the gold (I)- catalyzed asymmetric aldol reaction of isocyanoacetate with aldehydes. Six-membered ring amines, such as morpholino or piperidino group, at the terminal of the side chain were most stereoselective to give optically active trans-4-methoxycarbonyl-5-alkyl-2-oxazolines (up ...