Design and synthesis of novel potent antinociceptive agents: methyl-imidazolyl N-acylhydrazone derivatives
JM Figueiredo, C de A Câmara, EG Amarante…
文献索引：Figueiredo, Juliana M.; Camara, Celso De A.; Amarante, Emanuel G.; Miranda, Ana Luisa P.; Santos, Fulvia M.; Rodrigues, Carlos R.; Fraga, Carlos Alberto M.; Barreiro, Eliezer J. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 9 p. 2243 - 2248
This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl- imidazolyl-3-acylhydrazone class (4a–e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo [1, 2-a] pyridine 3-acylhydrazone series (2), which ...
