Inorganic Chemistry 2007-04-16

Platinum complex as a nanomolar protein kinase inhibitor.

Douglas S Williams, Patrick J Carroll, Eric Meggers

文献索引：Inorg. Chem. 46 , 2944, (2007)

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摘要

A pyridocarbazole platinum complex, which matches the overall shape of the natural product staurosporine, binds with high affinity at the adenosine triphosphate binding site of glycogen synthase kinase 3 (GSK-3alpha).